Recent Publications


Mathematical modeling of iron acquisition and stress response in Aspergillus fumigatus.
Brandon M, Howard B, Lawrence C, Laubenbacher R.
BMC Systems Biology. 19/09/2015

The Alternaria genomes database: a comprehensive resource for a fungal genus comprised of saprophytes, plant pathogens, and allergenic species.
Dang HX, Pryor B, Peever T, Lawrence CB.
BMC Genomics. (2015) Mar 25;16(1):239. doi10.1186/s12864-015-1430-7. PubMed PMID: 25887485; PubMed Central PMCID:PMC4387663.


Discord between morphological and phylogenetic species boundaries: Incomplete lineage sorting and recombination results in fuzzy species boundaries in an asexual fungal pathogen.
Stewart JE, Timmer LW, Lawrence CB, Pryor BM, Peever TL.
BMC Evolutionary Biol. 2014 Mar 3;14(1):38. doi: 10.1186/1471-2148-14-38. PubMed PMID: 24593138; PubMed Central PMCID: PMC4015827.

On the role of the blue-light receptor WC-1 (LreA) in Alternaria alternata in spore formation and secondary metabolism.
Pruß S, Fetzner R, Seither K, Herr A, Pfeiffer E, Metzler M, Lawrence CB, Fischer R.
Appl Environ Microbiol. 2014 Feb 14. [Epub ahead of print] PubMed PMID: 24532063.

Fast allergen prediction using text classification techniques.
Dang HX, Lawrence CB.
Allerdictor. Bioinformatics. 2014 Jan 7.[Epub ahead of print] PubMed PMID: 24403538.

Alternaria Comparative Genomics: The Secret Life of Rots.
Dang H and Lawrence C.
In Dean R, Lichens-Park A, and Kole C (Eds), Genomics of Plant-Associated Fungi and Oomycetes:Dicot Pathogens. Springer, 2014 (pp. 45-64).

Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model.
Namvar S, Warn P, Farnell E, Bromley M, Bowyer P, Herrick S.
Clin Exp Allergy. 2014 Oct 1. doi: 10.1111/cea. 12426.

Role of the Alternaria alternata blue-light receptor LreA (white-collar 1) in spore formation and secondary metabolism.
Pruss S, Fetzner R, Seither K, Herr A, Pfeiffer E, Metzler M, Lawrence CB, Fischer R.
Appl Environ Microbiol. 2014 Apr;80(8):2582-91. doi: 10.1128/AEM.00327-14. Epub 2014 Feb 14.

Elevated levels of the neutrophil chemoattractant PPBP in macrophages from individuals with chronic and allergic aspergillosis.
Smith NL, Bromley MJ, Denning DW, Simpson A, Bowyer P.
J Infect Dis. 2014 Sep 5. pii: jiu490.

A novel antifungal is active against Candida albicans biofilms and inhibits mutagenic acetaldehyde production in vitro.
Nieminen MT, Novak-Frazer L, Rautemaa V, Rajendran R, Sorsa T, Ramage G, Bowyer P, Rautemaa R.
PLoS One. 2014 May 27;9(5):e97864. doi: 10.1371/journal.pone.0097864

Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in CCPA, and novel associations of VEGFA, DENND1B and PLAT.
Smith NL, Hankinson J, Simpson A, Denning DW, Bowyer P.
Clin Microbiol Infect. 2014 Apr 8. doi: 10.1111/1469-0691.12643.

A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis.
Smith NL, Hankinson J, Simpson A, Bowyer P, Denning DW.
Clin Microbiol Infect. 2014 Aug;20(8):O480-8. doi: 10.1111/1469-0691.12473.

Prevalence, persistence, and phenotypic variation of Aspergillus fumigatus in the outdoor environment in Manchester, UK, over a 2-year period.
Alshareef F, Robson GD.
Med Mycol. 2014 May;52(4):367-75.

Environmental fungicides and triazole resistance in Aspergillus.
Bowyer P, Denning DW.
Pest Manag Sci. 2014 Feb;70(2):173-8.
2-hydroxyisocaproic acid is fungicidal for Candida and Aspergillus species.
Sakko M, Moore C, Novak-Frazer L, Rautemaa V, Sorsa T, Hietala P, Järvinen A, Bowyer P, Tjäderhane L, Rautemaa R.
Mycoses. 2014 Apr;57(4):214-21.

Genetic and virulence variation in an environmental population of the opportunistic pathogen Aspergillus fumigatus.
Alshareef F, Robson GD.
Microbiology. 2014 Apr;160(Pt 4):742-51. doi: 10.1099/mic.0.072520-0. Epub 2014 Jan 24.

Biodegradation of polyester polyurethane during commercial composting and analysis of associated fungal communities.
Zafar U, Nzeram P, Langarica-Fuentes A, Houlden A, Heyworth A, Saiani A,Robson GD.
Bioresour Technol. 2014 Apr;158:374-7. doi: 10.1016/j.biortech.2014.02.077. Epub 2014 Mar 4.

Fungal succession in an in-vessel composting system characterized using 454 pyrosequencing.
Langarica-Fuentes A, Zafar U, Heyworth A, Brown T, Fox G, Robson GD.
FEMS Microbiol Ecol. 2014 May;88(2):296-308. doi: 10.1111/1574-6941.12293. Epub 2014 Feb 24


Voriconazole resistance in Aspergillus fumigatus: should we be concerned?
Denning DW, Bowyer P.
Clin Infect Dis. 2013 Aug;57(4):521-3.

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus.
Fraczek MG, Bromley M, Buied A, Moore CB, Rajendran R, Rautemaa R, Ramage G, Denning DW,Bowyer P.
J Antimicrob Chemother. 2013 Jul;68(7):1486-96.

Fermentative 2-carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans.
Marttila E, Bowyer P, Sanglard D, Uittamo J, Kaihovaara P, Salaspuro M, Richardson M, Rautemaa R.
Mol Oral Microbiol. 2013 Aug;28(4):281-91.

Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species.
Rizzetto L, Giovannini G, Bromley M, Bowyer P, Romani L, Cavalieri D.
PLoS One. 2013;8(2):e56651. doi: 10.1371/journal.pone.0056651. Epub 2013 Feb 18.

Major variations in Aspergillus fumigatus arising within aspergillomas in chronic pulmonary aspergillosis.
Howard SJ, Pasqualotto AC, Anderson MJ, Leatherbarrow H, Albarrag AM, Harrison E, Gregson L,Bowyer P, Denning DW.
Mycoses. 2013 Jul;56(4):434-41. doi: 10.1111/myc.12047. Epub 2013 Feb 1.

High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates.
Buied A, Moore CB, Denning DW, Bowyer P.
J Antimicrob Chemother. 2013 Mar;68(3):512-4. doi: 10.1093/jac/dks451. Epub 2012 Dec 2.

Analysis of global gene expression changes in human bronchial epithelial cells exposed to spores of the allergenic fungus, Alternaria alternata.
Babiceanu MC, Howard BA, Rumore AC, Kita H, Lawrence CB
Front Microbiol. 2013 Jul 19;4:196. doi: 10.3389/fmicb.2013.00196. eCollection 2013.


Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates.
Farnell E, Rousseau K, Thornton DJ, Bowyer P, Herrick SE.
Fungal Biol. 2012 Sep;116(9):1003-12. doi: 10.1016/j.funbio.2012.07.004. Epub 2012 Jul 20.

Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus.
Bowyer P, Mosquera J, Anderson M, Birch M, Bromley M, Denning DW. FEMS Microbiol Lett. 2012 Jul;332(1):10-9. doi: 10.1111/j.1574-6968.2012.02575.x. Epub 2012 May 21.
CADRE: the Central Aspergillus Data REpository 2012.
Mabey Gilsenan J1, Cooley J, Bowyer P.
Nucleic Acids Res. 2012 Jan;40(Database issue):D660-6. doi: 10.1093/nar/gkr971. Epub 2011 Nov 12.
Systems biology of infectious diseases: a focus on fungal infections.
Rodrigo Santamaría, Lisa Rizzetto, Michael Bromley, Teresa Zelante, Wanseon Lee, Duccio Cavalieri, Luigina Romani, Brian Miller, Ivo Gut, Manuel Santos, Philippe Pierre, Paul Bowyer, Misha Kapushesky.
Immunobiology.216(11): 1212-27 I

Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter.
Albarrag AM, Anderson MJ, Howard SJ, Robson GD, Warn PA, Sanglard D, Denning DW.
Antimicrob Agents Chemother. 55(11):5113-21.

Scanning Electron Microscopy and Fermentation Studies on Selected Known Maize Starch Mutants Using STARGEN Enzyme Blends.
Adams, J.M.M., Teunissen, P.J.M., Robson, G., Dunn-Coleman, N., Donnison, I.S. 2011.
Bioenergy Research, 4(3)

High-frequency triazole resistance found Innonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease.
Denning DW, Park S, Lass-Florl C, Fraczek MG, Kirwan M, Gore R, Smith J, Bueid A, Moore CB, Bowyer P, Perlin DS. 2011.
Clin Infect Dis. 2011 52(9):1123-9.